The Expression and Significance of LGR5 in Endometrial Cancer / 实用妇产科杂志
Journal of Practical Obstetrics and Gynecology
;
(12): 128-131, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-510028
ABSTRACT
Objective:
To investigate the expression of Leucine-rich repeat-containing G protein-coupled receptor 5(LGR5) in endometrial cancer(EC) and their relationship with clinicopathological characteristics.Methods:
Immunohistochemistry were performed to measure the LGR5 expression in EC(n =90) and normal endometrium tissue(n =30).The expression of LGR5 and its relationship with clinicopathological characteristics were analyzed.Results:
The expression of LGR5 was significantly higher in EC than that in normal tissue (63.3% vs 23.3%,P<0.001).The expression of LGR5 in < 1/2 myometrium infiltration group was higher than in ≥1/2 myometrium infiltration group(72.5% vs 33.3%,P =0.001).There was no significant difference between the expression of LGR5 in different group of age,histological type,histological differentiation,cervical stroma invasion,lymph node metastasis,FIGO stage(P > 0.05).Multivariate analysis showed that LGR5 was an independent influential factor of myometrium infiltration (OR =0.163,95% CI 0.034 ~ 0.772,P =0.022).Conclusions:
LGR5 is up-regulated in EC,and is correlated to myometrium infiltration.LGR5 may play an important role in EC tumorigenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Practical Obstetrics and Gynecology
Year:
2017
Type:
Article
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