Correlation between BRAF gene mutation and papillary thyroid carcinoma / 肿瘤研究与临床

ABSTRACT

Papillary thyroid carcinoma (PTC) is a common tumor in endocrine system with unclear pathogenesis. The study has shown that the stimulation of cell growth, differentiation and gene mutation factors act together on the thyroid gland cells to transform into tumor cells from normal cells. A variety of oncogenes and tumor suppressor genes are involved in the development of PTC. In recent years, the study has found that BRAF gene mutation has a close relationship with the pathogenesis and prognosis of PTC. Mutated BRAF gene affects the occurrence and development of PTC owing to the regulation by RAS protein kinase and the application of biological function by activating MAPK signaling pathways.