Optimization of the Extraction and Preparation Process of Total Terpene Constituents in Platycladi Seed / 中国药师

ABSTRACT

Objective:To investigate the optimal extraction and dripping pills preparation of total terpene constituents in platycladi seed. Methods:The extraction processes of ultrasound, reflux, microwave and homogenization were investigated by single factor tests. The effects of extraction time, temperature, solid-liquid ratio and extraction times on the extraction of total terpene constituents in platy-cladi seed were investigated by orthogonal tests. Orthogonal tests were used to investigate the effects of the ratio of polyethylene glycol 6000 to poloxamer 188, the ratio of drug to matrix, the temperature of liquid and the dropping process on the quality of dropping pills. Results:The homogeneous extraction was used, and the optimum extraction conditions were as follows the extraction time was 10 min, the temperature was 80℃, the solid-liquid ratio was 110, and extraction time was once. The best preparation process of drop-ping pills was as followsthe ratio of polyethylene glycol 6000 to poloxamer 188 was 51, the ratio of drug to matrix was 13, the temperature of liquid was 80℃ and the dropping distance was 10 cm. Conclusion: The method of homogeneous extraction is simple, which can break the materials and extract the active ingredients simultaneously. The preparation process of dropping pills is reasonable and feasible, which is easy for the production and application.