Pathology of Thrombotic Microangiopathy
Journal of the Korean Society of Pediatric Nephrology
;
: 6-12, 2013.
Article
in Korean
| WPRIM
| ID: wpr-51014
ABSTRACT
Thrombotic microangiopathy (TMA) is a microvascular thrombotic lesion caused by endothelial injury and subsequent formation of platelet rich thrombus. TMA is first described as a classical pathologic feature of HUS/TTP. Renal biopsy finding of TMA represents kidney involvement of HUS/TTP as well as other diseases such as malignant hypertension, drug toxicity, eclampsia, pre-eclampsia, and several systemic infections. Autoimmune diseases and transplant kidney sometime also have TMA. It is needed to consider a complete autoimmune work-up of patients presenting with TMA including tests for ANA, ANCA, and ADAMTS13 inhibitory antibodies, because there are several reports of association with TMA in patients of SLE, anti-phospholipid syndrome, and ANCA-associated vasculitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pre-Eclampsia
/
Autoimmune Diseases
/
Thrombosis
/
Biopsy
/
Blood Platelets
/
Antiphospholipid Syndrome
/
Antibodies, Antineutrophil Cytoplasmic
/
Transplants
/
Drug-Related Side Effects and Adverse Reactions
/
Eclampsia
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Journal of the Korean Society of Pediatric Nephrology
Year:
2013
Type:
Article
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