Optimization of Decoction Technology for Zhuanggufang Decoction Powder by Central Composite De-sign-response Surface Method / 中国药房
China Pharmacy
;
(12): 954-957, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-510166
ABSTRACT
OBJECTIVE:
To optimize the decoction technology of Zhuanggufang decoction powder.METHODS:
Central com-posite design with 2 factors and 5 levels was conducted to design the test,taking water (fold) and decoction time as independent variables,the extraction amount of icariin and extraction yield overall desirability value of as dependent variables,regression equa-tion were fitted;response surface method was used to optimize the decoction technology of Zhuanggufang decoction powder,and was verified. It was compared with the traditional decoction piece effect.RESULTS:
The optimized technology was decocted twice with 16-fold water,20 min each time;relative error of predicted and theoretical value by overall desirability value was 2.97%;af-ter decoction powder and piece decocted in the same conditions,the extraction amounts of icariin were 1.2343 μg/g and 1.1324μg/g,extraction yields were 23.73% and 17.84%,respectively.CONCLUSIONS:
Central composite design-response surface meth-od optimizing decoction technology is simple and reliable,the optimized decoction technology is stable and feasible,and the decoc-tion capability of Zhuanggufang decoction powder is better than the traditional pieces.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Pharmacy
Year:
2017
Type:
Article
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