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Expression and clinical significance of PD-L2 molecule on monocytes of peripher-al blood in systemic lupus erythematosus / 中国免疫学杂志
Chinese Journal of Immunology ; (12): 414-417, 2017.
Article in Chinese | WPRIM | ID: wpr-510459
ABSTRACT

Objective:

To analyze PD-L2 expression on monocytes of peripheral blood cells in systemic lupus erythematosus ( SLE) and it′s correlation with the degree of disease activity .

Methods:

Peripheral blood of 26 cases of SLE patiens and 38 cases of healthy controls were collected .Peripheral blood mononuclear cells ( PBMC) were isolated and realtime PCR was carried on to analyze the PD-L2 gene expression.At the same time flow cytometry was performed to analyze the CD 14 and PD-L2 expression.

Results:

PD-L2 was significantly up-regulated on monocytes in RA patients than in healthy controls and had correlation with the disease activity and the SLEAI score.

Conclusion:

These findings help to clarify the function of PD-L2,including its potential role as a biomarker for SLE .

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Immunology Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Immunology Year: 2017 Type: Article