Expression and clinical significance of PD-L2 molecule on monocytes of peripher-al blood in systemic lupus erythematosus / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 414-417, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-510459
ABSTRACT
Objective:
To analyze PD-L2 expression on monocytes of peripheral blood cells in systemic lupus erythematosus ( SLE) and it′s correlation with the degree of disease activity .Methods:
Peripheral blood of 26 cases of SLE patiens and 38 cases of healthy controls were collected .Peripheral blood mononuclear cells ( PBMC) were isolated and realtime PCR was carried on to analyze the PD-L2 gene expression.At the same time flow cytometry was performed to analyze the CD 14 and PD-L2 expression.Results:
PD-L2 was significantly up-regulated on monocytes in RA patients than in healthy controls and had correlation with the disease activity and the SLEAI score.Conclusion:
These findings help to clarify the function of PD-L2,including its potential role as a biomarker for SLE .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2017
Type:
Article
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