Effects of 4 Flavonoids from Scutellaria Baicalensis on Different Cancer Cell Lines / 世界科学技术-中医药现代化

ABSTRACT

Wogonoside,wogonin,baicalin and baicalein are major chemical constituents of S.baicalensis.Baicalin,baicalein and wogonin have been reported previously to exert anti-cancer effects.The present study compared the anti-cancer effects of the four flavonoids individually towards four human cancer cell lines after 24-and 48-hour treatment based on cell viability assay.As a result,wogonin inhibited the growth of the four cell lines.The IC50 values after 48 hours of incubation were 97.9 μM for A549 lung adenocarcinoma cells,while 15.3 μM for HeLa cervical carcinoma cells,147 μM for HepG2 hepatocellular carcinoma cells and 104 μM for MCF-7 breast adenocarcinoma cells.In contrast,wogonoside,the glycoside of wogonin,showed no inhibitory effect against any one of the four cell lines.Baicalein inhibited the growth of HeLa cells,while baicalin inhibited the growth of HepG2 cells,both with higher IC50 values and less potent than wogonin.These findings established wogonin as the most active anti-cancer agent among the four major flavonoids of S.baicalensis.Since baicalin,the most abundant flavonoid in the herb,was found to enhance the growth of MCF-7 cells.Clinical applications of ingredients from S.baicalensis to the treatment of cancer should be carried out with purified compounds.