Relationship between neurosteroids and neuropsychiatric disorders such as anxiety and depression:research advances / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 236-239, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-510952
ABSTRACT
Neurosteroids are synthesized from cholesterol within the microglia of the central nervous system. They are classi?fied as dehydroepiandrosterone,progesterone,pregnenolone,allopregnanolone and other peripheral steroids. Neurosteroids such as al?lopregnanolone are positive allosteric modulators of GABAA receptors and exert anxiolytic and antidepressant-like behavior. Neuroac?tive steroids play a significant role in neurodevelopment in terms of internal environment homeostasis. This paper reviews the biosynthe?sis,metabolism regulatory effect on the response to stress and therapeutic potentials of neurosteroids.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Pharmaceutical Research
Year:
2017
Type:
Article
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