Effects of levofloxacin on serum CRP and WBC in community-acquired pneumonia / 中国生化药物杂志

ABSTRACT

Objective To investigate the effects of levofloxacin in the treatment of community-acquired pneumonia and the influence on serum levels of c-reactive protein(CRP)and white blood cell(WBC).Methods 60 patients with community acquired pneumonia from January 2010 to December 2013 in Affiliated Hospital of Ningbo University Medical College were selected and divided into control group(n=30)and research group(n=30),the control group was treated with amoxicillin potassium clavulanate joint azithromycin,the research group was treated with levofloxacin,the clinical effect,clinical symptoms disappear time,CRP,WBC,immune function and safety of two groups were compared.Results There was no significant difference in the efficiency of the two groups.The fever,cough and lung wet rale disappearing time of research group was(3.23±0.48)d,(7.84±1.12)d,(8.26±1.18)d,less than the control group(4.69±0.66)d,(9.30±1.34)d,(9.87±1.43)d,the difference was statistically significant(P<0.05).After treatment,the CRP,WBC of research group was(29.54±4.15)mg/L,(7.11±1.10)×109/L,lower than the control group(36.41±5.17)mg/L,(8.25±1.15)×109/L,the difference was statistically significant(P<0.05).The immune function of research group was improved more significantly than control group,the difference was statistically significant(P<0.05).There was no significant difference in safety between the two groups.Conclusion The effect is reliable of levofloxacin treatment of community-acquired pneumonia,and can decrease the serum level of CRP and WBC.