Cytotoxicity of Ibuprofen Raw Material and its Part of Impurities / 中国药师
China Pharmacist
;
(12): 769-771, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-511637
ABSTRACT
Objective:
To evaluate the cytotoxicity of ibuprofen and its 6 kinds of impurities.Methods:
Different concentrations of ibuprofen and the impurities were used to act on mouse fibroblasts (L929) for 72 h,and the cytotoxicity was observed under a microscope.Results:
In ibuprofen raw material,the cytotoxicity of impurity B was the weakest with slight toxicity,the cytotoxicity of impurity N,D,J and V was moderate,and that of impurity E was severe.Conclusion:
At the same concentration,the toxicity of impurity E is the strongest,and its content in ibuprofen preparations should be strictly controlled.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2017
Type:
Article
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