The Effect of Korean Red Ginseng on Symptoms and Quality of Life in Chronic Tinnitus: A Randomized, Open-Label Pilot Study
Journal of Audiology & Otology
;
: 85-90, 2015.
Article
in English
| WPRIM
| ID: wpr-51192
ABSTRACT
BACKGROUND AND OBJECTIVES:
The major mechanism of inner ear cell damage is the production of reactive oxygen species (ROS). Korean red ginseng (KRG) has an anti-ROS effect; thus we hypothesized that KRG may be of use for the treatment of chronic idiopathic tinnitus. The aim of the study is to investigate clinical outcomes and health-related quality of life (QoL) in chronic tinnitus patients after taking KRG. SUBJECTS ANDMETHODS:
This study was an open-label randomized controlled trial. Sixty-one patients with chronic tinnitus were enrolled and randomized to three groups. The control group was treated for 4 weeks with 160 mg/day Ginkgo biloba extract, and two other groups receiving 1500 mg/day or 3000 mg/day KRG for 4 weeks. Clinical assessments were performed using the tinnitus handicap inventory (THI), Visual Analogue Scale (VAS) and QoL was assessed by Short Form-36 Health Survey (SF-36) questionnaire.RESULTS:
Fifty-nine patients completed the planned protocol. Significant improvements were observed between initial and post-treatment THI scores in patients receiving 3000 mg/day KRG. There was no statistically significant difference between initial and post-treatment VAS scores in all groups. Treatment with 3000 mg/day KRG for 4 weeks significantly improved role emotional and mental health scores in the SF-36 survey.CONCLUSIONS:
These results suggest that KRG may improve tinnitus symptoms and mental wellbeing in chronic tinnitus patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Tinnitus
/
Pilot Projects
/
Mental Health
/
Health Surveys
/
Reactive Oxygen Species
/
Ginkgo biloba
/
Panax
/
Ear, Inner
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Practice guideline
Limits:
Humans
Language:
English
Journal:
Journal of Audiology & Otology
Year:
2015
Type:
Article
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