Research progress of AIM2 in tumor / 实用肿瘤学杂志
Practical Oncology Journal
;
(6): 175-178, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-512044
ABSTRACT
Absent in melanoma 2(AIM2),as a cytoplasmic DNA sensor,can perceive the cytoplasmic dsDNA which released by the cells infected with DNA virus or bacteria.AIM2 will be raised by Apoptosis-associated speck-like protein containing a CARD to produce inflammation complex,activate of Caspase-1,promote the maturation,and secretion of IL-1β and IL-18,or lead to pyroptosis.AIM2 plays an importation role in initiating immunity.Recent research shows that AIM2 has an influence on the occurrence and progress in tumor,it acts as a tumor suppressor and inhibits tumor progression in liver and breast carcinoma;However,AIM2 shows the carcinogenic effect of promoting tumor development on cervical carcinoma and oral squamous cell carcinoma.These results contribute to the diagnosis and prognosis of malignant tumor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Practical Oncology Journal
Year:
2017
Type:
Article
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