Clinical observation of sertraline in the treatment of coronary heart disease complicated with depression after percutaneous coronary intervention / 中国基层医药

ABSTRACT

Objective To investigate the clinical effect of sertraline in the treatment of coronary heart disease (CHD) complicated with depression after percutaneous coronary intervention.Methods According to random number table,73 CHD patients complicated with depression after percutaneous coronary intervention were randomly divided into observation group(37 cases) and control group(36 cases).The control group was treated by CHD conventional therapy and shallow psychological intervention,and the observation group was treated with sertraline on the basis of the control group.The clinical efficacy,SDS and HAMD score,changes of SP-selectin,hs-CRP,IL-6,TNF-α,NO and ET-1 levels were compared.Results The total effective rate of the observation group was 97.30％,which was significantly higher than 88.89％ of the control group (Z =-5.541,P =0.000).The HAMD and SDS scores of the two groups were significantly decreased (tobservation group (HAMD) =10.600,P =0.000;tcontrol group (HAMD) =5.214,P =0.000;tobservation group(SDS) =14.844,P =0.000;tcontrol group(SDs) =6.863,P =0.000),and those of the observation group were significantly lower than the control group (tHAMD =--6.539,P =0.000;tSDs =--8.254,P =0.000).The levels of SP-selectin (t =3.759,P =0.000),hs-CRP (t =2.956,P =0.004) in the observation group and IL-6 (tob ion group =9.969,P =0.000;tcontrol group =5.059,P =0.000),TNF-α (tobservation group =10.596,P =0.000;tcontrol group =2.615,P =0.011),ET-1 (tobservation group =4.670,P =0.000;tcontrol group =2.264,P =0.027) in the two groups were significantly decreased,and the NO (tobservtion group =-5.482,P =0.000;tcontrol group =-4.027,P =0.000) increased.Also,the levels of SP-selectin (t =-2.715,P =0.008),hs-CRP (t =-2.089,P =0.040),IL-6 (t =-4.975,P =0.000) and TNF-α (t =-6.832,P =O.000) in the observa tion group were significantly lower than those in the control group.Conclusion Sertraline has significant clinical effi cacy in the treatment of CHD complicated with depression after percutaneous coronary intervention.It can effectively reduce the HAMD and SDS scores,improve the depressive symptoms,reduce the expression of SP-selectin and relat ed inflammatory factors.It is worthy of popularization and application.