The diagnostic value of serum AMH, IGF-1 and IGFBP-1 levels in polycystic ovarian syndrome / 中国基层医药

ABSTRACT

Objective To explore the relation between serum AMH,IGF-1 and IGFBP-1 levels and polycystic ovarian syndrome (PCOS) and its clinical significance.Methods Serum levels of AMH,IGF-1 and IGFBP-1 were measured by ELISA in 80 patients with PCOS and 80 healthy subjects.Results The levels of serum AMH,IGF-1,IGFBP-1 in PCOS group were (7.18 ± 1.50) ng/L,(200.85 ± 27.78) ng/L,(4.05 ± 0.65) ng/L respectively,which in the control group were (3.70 ± 1.01) ng/L,(110.58 ± 12.50) ng/L,(8.16 ± 1.39) ng/L.The serum levels of AMH,IGF-1 in the PCOS group were significandy higher than those in the control group(t =13.14,26.80,P ＜ 0.01),while the serum level of IGFBP-1 in the PCOS group was significantly lower than that in the control group(t =16.28,P ＜0.01).The serum levels of AMH,IGF-1,IGFBP-1 in patients with obese group were (7.18 ± 1.50) ng/L,(200.85 ± 27.78) rng/L,(4.05 ± 0.65)ng/ L respectively,which in the non-obese group were (15.52 ± 2.41) ng/L,(143.85 ± 15.61) ng/L,(6.75 ± 0.93) ng/L.The serum level of IGF-1 in the obese group was significantly higher than that in the non-obese group(t =10.87,P ＜0.01),while the serum levels of AMH and IGFBP-1 in the obese group were significandy lower than those in the non-obese group(t =18.98,15.27,P ＜0.01).Conclusion Serum AMH,IGF-1 and IGFBP-1 may be involved in the pathogenesis and obesity of PCOS,which may be associated with the pathogenesis of PCOS.