Observation of the effect of piracetam combined with edaravone in the treatment of patients with acute cerebral infarction / 中国基层医药

ABSTRACT

Objective To investigate the clinical efficacy of piracetam combined with edaravone in the treatment of patients with acute cerebral infarction.Methods 120 patients with acute cerebral infarction were selected,and they were randomly divided into control group and observation group according to the digital table,60 cases in each group.The patients in both two groups were treated with mannitol to reduce intracranial pressure,aspirin antiplatelet aggregation,combined with basic nutritional support,active prevention and treatment of complications.The control group was intravenously given piracetam.On this basis,the observation group was intravenously given edaravone injection.Both two groups were treated for 14 days.The clinical curative effect,neurological deficit and self-care ability score before and after treatment were observed,and the indicators of hemorheology before and after treatment were observed.Results Mter treatment,the neurological deficit and self-care ability scores of the two groups were significantly improved(t =3.43,4.12,5.67,6.89,all P ＜ 0.05),the improvements of the observation group were significantly better than those of the control group(t =2.10,4.21,all P ＜ 0.05).The total effective rate of the observation group was 85.00％,which was higher than 70.00％ of the control group,the difference was statistically significant (x2 =4.11,P ＜ 0.05).After treatment,the indicators of hemorheology of the two groups were significantly improved (t =1.43,2.98,2.32,4.56,1.67,2.11,1.46,1.98,all P ＜ 0.05),and the improvements of the observation group were significantly better than those of the control group (t =1.46,2.32,1.67,1.39,all P ＜ 0.05).Conclusion Piracetam combined with edaravone can significantly improve the neurological function,cognitive function and hemorheology of patients with acute cerebral infarction.