The change and significance of IL-23and IL-17 levels in peripheral blood of patients with OSAHS / 安徽医科大学学报

ABSTRACT

To investigate the change and clinical significance of interleukin(IL)-23 and IL-17 levels preliminarily in peripheral blood of patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).The levels of IL-23 and IL-17 in serum and culture supernatants of peripheral blood mononuclear cells(PBMCs)were determined by ELISA in patients with OSAHS and normal volunteers.To observe the changes of IL-23 and IL-17 levels before and after the treatment of Han-uvulopalatopharyngoplasty(H-UPPP) in patients with OSAHS.The levels of IL-23 and IL-17 in serum and culture supernatants of PBMCs in patients with OSAHS were significantly higher than those in normal control group(P<0.05),and the levels of serum IL-23 and IL-17 were increased with the disease severity.The levels of IL-23 presented positively correlated with those of IL-17 in both serum and culture supernatants of PBMCs(rs=0.644,P<0.01;rs=0.251,P<0.05).After two months later of H-UPPP surgery, the levels of serum IL-23 and IL-17 were significantly lower than that before the treatment(P<0.05)as well as the apnea-hypopnea index.The sleep quality and low oxygen was improved obviously, and the lowest oxyhemoglobin saturation elevated significantly(P<0.05).IL-23 and IL-17 may play an important role in pathogenesis and prognosisof OSAHS.