Efficacy of osteoporosis atorvastatin combined with alendronate in the treatment of senile and its effects on tumor necrosis factor-α and interleukin 6 / 中国综合临床

ABSTRACT

Objective To investigate the effect of atorvastatin combined with alendronate in the treatment of senile osteoporosis.Methods One hundred and sixty cases patients with osteoporosis were randomly divided into control group and study group,each group had 80 cases.Control group were received alendronate sodium tablets 70 mg weekly,alfacalcidol soft capsules,2 tablets daily,calcium carbonate tablets D 3,2 tablets daily.Study group received atorvastatin calcium 1 tablet daily based on control group.Twenty weeks were a course.Biochemical indicators(collagen amino terminal peptide(NTX),25-hydroxyitamin D,alkaline phosphatase(ALP),bone growth protein(BGP),parathyroid hormone(PTH),collagen type Ⅰ carboxyl terminal peptide(CTX) level),inflammatory factors(TNF α,IL-6) and visual analogue scale(VAS),bone mineral density(BMD) were compared between two groups.Results After treatment,VAS scores in both groups decreased significantly,while,VAS in study group((1.8±0.4) points) was significantly lower than that in control group((2.6±0.7) points,t=8.87,P<0.05).BMD in different parts in both groups increased significantly,while BMD in different parts in study group(femoral neck(0.90±0.08) g/cm3,lumbar vertebra(0.98±0.04) g/cm3,oblique eminence of cuboid bone(0.79±0.04) g/cm3,femur(0.98±0.07) g/cm3) were significantly higher than that in control group(femoral neck(0.82±0.09) g/cm3,lumbar vertebra(0.92±0.06) g/cm3,oblique eminence of cuboid bone(0.72±0.05) g/cm3,femur(0.90±0.06) g/cm3,t=5.94,7.44,9.78,7.76,P<0.05).NTX,PTH,CTX in both groups decreased significantly,while,NTX((10.3±2.8) nmlo/L),PTH((4.4±1.1) μg/L),CTX((0.3±0.1) μg/L) in study group was significantly lower than that in control group(NTX(13.2±3.6) nmlo/L,PTH(4.9±1.3) μg/L,CTX(0.4±0.1) μg/L,t=5.69,2.63,6.32,P<0.05).And 25-hydroxy-vitamin D,ALP,BGP in both groups increased significantly,while 25-hydroxy-vitamin D in study group((20.4±3.7) ng/mL) was significantly higher than that in control group((18.6±3.5) μg/L).TNF-α,IL-6 in both groups decreased significantly(before treatmentTNF-α,IL-6 in study group were (9.0±2.3) μg/L,(167.2±55.6) μg/L,in control group were (8.9±2.5) μg/L,(162.5±68.4) μg/L),while,TNF-α,IL-6 in study group was significantly lower than that in control group((3.7±1.2) μg/L vs.(5.6±1.5) μg/L,(69.8±16.7) μg/L vs.(118.4±32.4) μg/L,(9.0±2.3) μg/L vs.(8.9±2.5) μg/L,t=8.85,11.93,P<0.05).Conclusion Atorvastatin combined with alendronate sodium can effectively improve BMD in OP patients,relieve pain and improve clinical symptoms.