The correlation between neonatal respiratory distress syndrome and Surfactant protein B genetic polymorphisms in the Mongol nationality from Inner Mongolia / 中华急诊医学杂志

ABSTRACT

Objective To study the association between the SP-B gene 1580 position polymorphisms and neonatal respiratory distress syndrome (NRDS) in the Mongol nationality from Inner Mongolia.To observe the frequency distribution of polymorphisms of SP-B gene 1580 position in the Mongol nationality newborns from Inner Mongolia.Methods The genotypes of SP-B gene 1580 position were detected by using polymerase chain reaction-restriction fragmnent length polymorphism assay and gene sequencing in 323 Mongol nationality newborns including the case group and the control group.The SP-B 1580C/T allele frequencies of the Mongol nationality newborns were compared with those of Han nationality from Wuhan city,German Caucasian,American Caucasian and Japanese.Results In the case group,the frequencies of TT,TC,CC at SP-B gene 1580 position were 19.9％,37.1％ and 43.0％,respectively;the frequency of the T allele was 38.4％ and C allele was 61.6％.In the control group,the frequencies of TT,TC,CC at SP-B gene 1580 position were 25.2％,39.7％ and 35.1％,respectively;the frequency of the T allele was 47.0％ and C allele was 53.0％.There were no significant differences between the case group and the control group (x2 =2.299,P =0.317).The allele frequencies of SP-B 1580 of the Mongol nationality newborns were significantly different from those of German-Caucasian and American-Caucasian (P ＜ 0.05),but were similar to those of Han nationality from Wuhan city and Japanese (P ＞ 0.05).Conclusions SP-B 1580C/T gene polymorphism in the Mongol nationality newborns displays no significant correlation with sex,birth weight or gestational age.There is no obvious correlation between SP-B gene 1580 position polymorphisms,allele frequency and the Mongol nationality NRDS.There is heterogeneity in the frequencies of polymorphisms of SP-B 1580 among different ethnic genes.