Ameliorative effect of myricetin on insulin resistance in mice fed a high-fat, high-sucrose diet
Nutrition Research and Practice
;
: 544-549, 2014.
Article
in English
| WPRIM
| ID: wpr-51346
ABSTRACT
BACKGROUND/OBJECTIVES:
Obesity-associated insulin resistance is a strong risk factor for type 2 diabetes mellitus. The aim of this study was to investigate the effect of myricetin on adiposity, insulin resistance, and inflammatory markers in mice with diet-induced insulin resistance. MATERIALS/METHODS:
Five-week-old male C57BL/6J mice were fed a basal diet, a high-fat, high-sucrose (HFHS) diet, or the HFHS diet containing 0.06% myricetin or 0.12% myricetin for 12 weeks after a 1-week adaptation, and body weight and food intake were monitored. After sacrifice, serum lipid profiles, glucose, insulin, adipocyte-derived hormones, and proinflammatory cytokines were measured. The homeostasis model assessment for insulin resistance (HOMA-IR) was determined.RESULTS:
Myricetin given at 0.12% of the total diet significantly reduced body weight, weight gain, and epidydimal white adipose tissue weight, and improved hypertriglyceridemia and hypercholesterolemia without a significant influence on food intake in mice fed the HFHS diet. Serum glucose and insulin levels, as well as HOMA-IR values, decreased significantly by 0.12% myricetin supplementation in mice fed the HFHS diet. Myricetin given at 0.12% of the total diet significantly reduced serum levels of leptin, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in mice fed the HFHS diet.CONCLUSIONS:
These findings suggest that myricetin may have a protective effect against diet-induced obesity and insulin resistance in mice fed HFHS diet, and that alleviation of insulin resistance could partly occur by improving obesity and reducing serum proinflammatory cytokine levels.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Glucose
/
Body Weight
/
Insulin Resistance
/
Hypertriglyceridemia
/
Weight Gain
/
Risk Factors
/
Cytokines
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Leptin
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Nutrition Research and Practice
Year:
2014
Type:
Article
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