Remodeling of Skeletal Muscle Extracellular Matrix and Insulin Resistance (review) / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
;
(12): 398-401, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-513761
ABSTRACT
Skeletal muscle extracellular matrix (ECM) is the microenvironment for muscle cells to survive and function. Changes in ECM components and structure directly affect the activity and function of muscle cells. Pathological remodeling occurs to skeletal muscle ECM in insulin resistance, including collagen deposition, hyaluronan accumulation, activation of membrane protein integrin signaling path-way, and the imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases, while all those would impair the tissue insu-lin sensitivity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Rehabilitation Theory and Practice
Year:
2017
Type:
Article
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