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Risk factors and prognosticsignificance of positive peritoneal cytology in endometrial cancer / 基础医学与临床
Basic & Clinical Medicine ; (12): 448-453, 2017.
Article in Zh | WPRIM | ID: wpr-513795
Responsible library: WPRO
ABSTRACT
Objective To determine the prognostic significance of positive peritoneal cytology (PPC) among patients with endometrial cancer and to find out potential risk factors for PPC in endometrial cancer.Methods Data were extracted from Peking Union Medical College Hospital between Jan 1 2005 and Dec 31 2010.Only those patients who had undergone a staging procedure were included.A total of 486 patients were identified.Statistical analyses were performed using Fisher`s exact test, Kaplan-Meier log rank, and Cox proportional hazards models.ResultsRate of PPC was 4.8% in endometrial cancer.Non-endometrioid endometrial cancer(P=0.000), stage Ⅲ/Ⅳ(P=0.000), deep myometrial invasion(P=0.001), and cervical stromal involvement(P=0.018) appeared to be risk factors for PPC in endometrial cancer.Univariate analysis revealed statistically difference in 5-year PFS (70.9% vs 90.0%) and 5-year OS (72.2% vs 96.0%).Progression-free survival and overall survival showedstatistically difference(P=0.005,P=0.000)between PPC and NPC endometrial cancer.On multivariate analysis, PPC remained no statistically difference in progression-free survival or overall survival(RR=3.812,95% CI 0.897-16.200,P=0.070;RR=3.426,95% CI 0.800-14.673,P=0.097).Conclusions PPC is not an independent risk factor in patients with endometrial cancer.Aggressive histology, FIGO stage, deep myometrial invasion and cervical stromal involvement are presumed to be associated with PPC in endometrial cancer.
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Full text: 1 Index: WPRIM Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: Zh Journal: Basic & Clinical Medicine Year: 2017 Type: Article
Full text: 1 Index: WPRIM Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: Zh Journal: Basic & Clinical Medicine Year: 2017 Type: Article