Effect of Anorexia and Neuropathic Pain Induced by Cisplatin on Hindlimb Muscles of Rat
Journal of Korean Academy of Nursing
;
: 361-369, 2013.
Article
in Korean
| WPRIM
| ID: wpr-51394
ABSTRACT
PURPOSE:
The purpose of this study was to examine the effect of anorexia and neuropathic pain induced by cisplatin on hindlimb muscles of rats.METHODS:
Adult male Sprague-Dawley rats were divided into two groups, a cisplatin-treated group (n=10) and a control group (n=10). In the cisplatin-treated group, cisplatin at a dose of 2 mg/kg was injected intraperitoneally two times a week up to a cumulative dose of 20 mg/kg over 5 weeks, and in the control group saline (0.9% NaCl) was injected intraperitoneally at the same dose and duration as the cisplatin-treated group. At 34 days all rats were anesthetized, after which the soleus and plantaris muscles were dissected. Withdrawal threshold, body weight, food intake, activity, muscle weight, Type I and II fiber cross-sectional areas and myofibrillar protein content of the dissected muscles were determined.RESULTS:
Compared with the control group, the cisplatin-treated group showed significant decreases (p<.05) in withdrawal threshold, activity, food intake, body weight, Type I and II fiber cross-sectional areas, myofibrillar protein content and weight of the soleus and plantaris muscles.CONCLUSION:
Muscular atrophy in hindlimb occurs due to anorexia and neuropathic pain induced by the cisplatin treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Body Weight
/
Anorexia
/
Cisplatin
/
Rats, Sprague-Dawley
/
Muscle, Skeletal
/
Muscle Fibers, Skeletal
/
Eating
/
Hindlimb
/
Injections, Intraperitoneal
/
Motor Activity
Limits:
Animals
Language:
Korean
Journal:
Journal of Korean Academy of Nursing
Year:
2013
Type:
Article
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