Investigation of hemostatic disorders in patients with congenital heart diseases undergoing open heart surgery at Hue Central Hospital
Journal of Medical Research
;
: 55-62, 2007.
Article
in Vietnamese
| WPRIM
| ID: wpr-514
ABSTRACT
Background:
Open heart surgery with cardiopulmonary bypass (CPB) causes haemostatic abnormalities which result in postoperative excessive bleeding.Objectives:
To investigate haemostatic disorders before - after CPB and postoperative bleeding. Subjects andmethods:
Sixty congenital cardiac patients with and without cyanosis were recruited consecutively. Hematology and coagulation tests were done 1 day before operation, 15 minutes after protamine administration, 2 and 6 hours after the operation in the intensive care unit (lCU). Mediastinal chest tube drainage (MCTO) was measured for the first 6h in the ICU.Results:
Significant differences between 2 groups could be found for red blood cells, hemoglobin, hematocrit, fibrinogen, D-dimer, fibrinogen degradation products (FOP), von Kaulla and platelet aggregation to epinephrine before operation (p < 0.05). There were not significant differences in platelets, PT, APTT, platelet aggregation to adenosine diphosphate (AOP) in the acyanotic and cyanotic patients (p > 0.05). Most hematology parameters were decreased significantly and hemostasis measurements were prolonged after operation in both groups (p < 0.05). There was also the significant difference in MCTO between 2 groups (p < 0.05).Conclusion:
Coagulation, hemostasis and fibrinolysis disorders; thrombocytopenia and acquired transient platelet dysfunction may be responsible for bleeding complications after CBP \r\n', u'\r\n', u'
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Epidemiology
/
Hemostatic Disorders
/
Diagnosis
Type of study:
Diagnostic study
Language:
Vietnamese
Journal:
Journal of Medical Research
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS