Advances in the changes of the regulatory regions of congenital heart disease related genes / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 77-79, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-514141
ABSTRACT
Congenital heart disease is defined as a large group of structural and functional deficits that arise during cardiac embryogenesis,which poses serious threat to children's health.Genetic factors play an important role in the pathogenesis of congenital heart disease.Except for disease-related gene coding regions,recent research suggests that regulatory regions of these genes also participate in its occurrence.Regulatory elements include promoter,enhancer and attenuator,etc.This article reviews the relationship between the changes of these elements and the pathogenesis of congenital heart disease in order to better clarify the underlying mechanism and bring new ideas for clinical managements.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2017
Type:
Article
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