Mitochondrial fusion and fission in the pathogenesis of sepsis / 国际儿科学杂志

ABSTRACT

Sepsis is a systemic inflammatory response syndrome caused by infection,and further development can lead to septic shock and multiple organ dysfunction syndrome.Clinical research of sepsis morbidity and mortality is a hot topic in this field.Subcellular related studies in recent years show that mitochondrial damage plays a very important role in the development of sepsis,especially septic shock.Mitochondria are highly dynamic organelles in the cell.They continue to merge and divide within cells,forming a dynamic equilibrium network structure.In sepsis,imbalance of mitochondrial fusion and fission leads to disorders of the intracellular molecules,cells,and organs.This article reviews the progress in the investigation of mitochondrial fusion and fission in the pathogenesis of sepsis.