Ryanodine receptor phosphorylation in sepsis-induced cardiomyopathy / 国际儿科学杂志

ABSTRACT

Sepsis is a systemic inflammatory reaction caused by infection,which is a common complication after bum,serious trauma,major surgery,pathological obstetrics,toxication and cardiopulmonary resuscitation.Simultaneously,it's also an important cause which can lead to septic shock and multiple organ dysfunction syndrome.Heart is the target of multiple organ dysfunction caused by sepsis,leading to different degrees of cardiac dysfunction by sepsis and vice verse.Ryanodine receptor is macromolecule composed by complex protein structure,which is the major component of Ca2+ channels.It's the necessary factor to adjust muscle,cardiac rhythm and contraction.It is also involved in regulating sarcoplasmic reticulum to release Ca2+.This article is to give a review of ryanodine receptors in cardiac dysfunction caused by sepsis.