Advances in pancreatic β cell regeneration and transformation / 国际儿科学杂志

ABSTRACT

Type 1 diabetes mellitus (T1DM) is an organ-specific autoimmune disease caused by absolute lack of insulin secretion and progressive pancreatic β cell damage.Patients require lifelong subcutaneous injection of insulin.However,this treatment could induce great pain without improving long-term prognosis.Along with the medicine development,comprehensive methods including genetic technology are adopted to achieve pancreatic β cell regeneration and transformation.Protecting the function of remaining pancreatic β cells for T1DM patients provides a new insight in prevention of acute and chronic T1DM complications.Currents studies of islet β cell reconstruction focus on islet transplantation,stem cell transplantation and immune regulator applications.Unfortunately,owing to their limitations,these methods cannot satisfy clinical application.While transdifferentiation of pancreatic islet δ cells has become a hope recently because of its unique advantages.In this paper,we will summarize the technical methods,influence factors and possible mechanisms of the transdifferentiation of pancreatic islet δ cells.