Research progress on the role of CXC chemokines and their receptors in pancreatic cancer / 中华肝胆外科杂志

ABSTRACT

Chemokines participate in many biological functions including immune inflammatory response,various metabolic reactions and damage stress response.Meanwhile,they also play a crucial role in the process of tumor progression including regulating tumor proliferation,invasion and metastasis,and mediating immune cells infiltration and angiogenesis in tumor tissue as well as the tolerance to antitumor treatment.Pancreatic cancer is one of the highly malignant digestive system neoplasms with relatively high risk of early local invasion and distant metastasis,resulting in high mortality.At present,the specific mechanism of the development of pancreatic cancer has not been clarified yet.In recent years,the role of chemokine CXC (chemokine subfamily) and its receptor CXCR (CXC chemokine receptors) in pancreatic cancer has become a hot research topic and great progress has been made in this field.This paper overviewed the recent research advance on the functions of chemokine CXC and their receptors in pancreatic cancer.