Clinical significance of detection of serum myocardial enzymes and LDH,TNF-α of CSF in acute phase of adult intracranial infection / 重庆医学

ABSTRACT

Objective To investigate the value of detection of serum LDH,AST,CK and LDH and TNF-α of CSF in the acute phase of adult intracranial infection.Methods Seventy-seven patients with acute stage of intracranial infection in our hospital from January 2014 to December 2015 were selected as the observation group,and 60 patients with non-infectious nervous system diseases were selected as the control group.The levels of serum LDH,AST and CK,and LDH and TNF-α levels of CSF within 7 d after onset were compared between the two groups and the subgroup analysis was performed.Results The levels of serum LDH,AST and CK,and TNF-α and LDH of CSF in the infection group were significantly higher than those in the control group,the difference was statistically significant (P＜0.05);LDH level of CSF in the purulent meningitis and tuberculous meningitis groups was significantly higher than that in the viral encephalitis group (P＜0.05);the level of TNF-α of CSF in the purulent meningitis was significantly higher than that in the tuberculous meningitis and viral meningitis groups (P＜0.05).Conclsion Detecting serum LDH,AST and CK,and LDH and TNF-α levels of CSF is conducive to the auxiliary diagnosis of intracranial infection,meanwhile has a certain discriminating value for the causes of intracranial infection.