Neurodegenerative diseases and endoplasmic reticulum stress / 中华行为医学与脑科学杂志
Chinese Journal of Behavioral Medicine and Brain Science
;
(12): 183-187, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-514513
ABSTRACT
Neurodegenerative diseases,which are common nervous system diseases,seriously affect people''s life quality and even lives. So the pathogenesis of neurodegenerative diseases is attracting more and more attention in recent years. People gradually realize that endoplasmic reticulum stress is associated with the pathogenesis of many diseases through studying the function of the endoplasmic reticulum. Neurodegen-erative diseases, endoplasmic reticulum stress,unfolded protein responsewere used as the key words of retrieval performance in the databases such as Pubmed,CNKI and so on. And the papers which closely re-lated with the theme were chosen to investigate the association between alzheimer''s disease,parkinson''s dis-ease,Huntington'' s disease ,amyotrophic lateral sclerosis and ERS. It turned out that the expression of mo-lecular chaperone GRP78/Bip was increased in all neurodegenerative diseases, and the phosphorylation of eIF2α increased in most neurodegenerative diseases. However, the expression of some ERS-related factors was completely different in different neurodegenerative diseases. Thus,the study of ERS may be an important breakthrough for the pathogenesis and treatment of neurodegenerative diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Behavioral Medicine and Brain Science
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS