Research progress on the mechanism of long chain non-coding RNA regulating epithelial-mesenchymal transition of bladder cancer stem cells / 医学研究生学报

ABSTRACT

Bladder cancer is the most common malignant tumor in urogenital system. Bladder carcinoma has the biological characteristics of easy recurrence and metastasis. The cancer stem cells theory explained the mechanisms of bladder cancer recurrence and metastasis. Epithelial-mesenchymal transition ( EMT) could promote tumor cells to acquire stem cell characteristics, while the tumor cells with stem cell characteristics have correspondingly high expression of EMT biomarkers. Long noncoding RNA ( lncRNA) promotes tumor cells to acquire and maintain stem cell characteristics through regulating EMT process. CSCs, EMT and lncRNA are closely related to the genesis and development of tumors, and participate in the regulation process of tumor proliferation, invasion, me-tastasis and so on. It will provide new insights in targeting therapy of tumor metastasis and recurrence through illuminating the correla-tion between lncRNA on EMT of bladder cancer stem cells ( BCSCs) This article makes a review on the latest research progress about the mechanism of lncRNA regulating EMT of BCSCs.