Intraoperative radiotherapy for soft tissue sarcoma / 医学研究生学报

ABSTRACT

Soft tissue sarcoma ( STS) , which is mostly found in extremities and retroperitoneum, is a malignant tumor of the connective tissue with the low incidence ( 1% of all malignant tumors) and various kinds of histopathological types. Intraoperative radio-therapy ( IORT) can improve the therapeutic effects of STS and to reserve the functions of the related organs, holding the apparent ad-vantage in local control rate of the tumor. IORT may cause toxicity, such as wound infections, limb ischemic necrosis and fibrosis. However, with the gradual development of IORT equipment, incidence rate of toxicity may be further reduced. This paper reviews the history, indications and advantages, clinical efficacy and adverse effect of IORT in STS.