Clinical observation of diosmin combined with nimesulide in treatment of traumatic synovitis of knee joint / 药物评价研究

ABSTRACT

Objective To observe the clinical curative effect of diosmin combined with nimesulide in treatment of drugs for the traumatic synovitis ofin knee joint.Methods Sixty patients the People's Liberation Army 425 Hospital diagnosis standard and the requirements in this study were averagely and randomly divided into combination group,nimesulide group and diosmin group,the patients in combination group were given diosmin and nimesulide treatment,the patients in nimesulide group were given nimesulide treatment,diosmin group were given diosmin treatment.The course of treatment was 14 d.Then score knee joint VAS,AKS rating,and swelling degree in each group before and after the treatment.Results After treatment,the patients with knee joint swelling,pain degree are improved,the difference before and after treatment has statistical significance (P ＜ 0.05),meanwhile differences in the combination group were larger than the other two groups (P ＜ 0.05).Conclusion The drugs of nimesulide and diosmin for the treatment of traumatic synovitis respectively have certain effect,but the combined treatment curative effect is remarkable than used alone.Combination medication can be more obviously relieving the pain of patients and prevent disease progression,reduce inflammation which achieved a satisfactory therapeutic effect.