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Systematic review of the effectiveness of intratracheal injection of pulmonary surfactant in the treatment of neonatal respiratory distress syndrome / 临床儿科杂志
Journal of Clinical Pediatrics ; (12): 223-228, 2017.
Article in Zh | WPRIM | ID: wpr-515222
Responsible library: WPRO
ABSTRACT
Objective To evaluate the effectiveness of intratracheal injection of pulmonary surfactant (LISA) combined with continuous positive airway pressure (CPAP) on the treatment of neonatal respiratory distress syndrome (RDS). Methods The databases of PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure (CNKI), Wanfang Database, Weipu Database and China Biology Medicine disc (CBM) were searched, and all of the randomized controlled trial of LISA combined with CPAP for treatment of RDS were included. RevMan 5.2 was used to perform meta-analysis. The differences of mortality, bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), and other complications between LISA group and control group were compared in 0.05). Conclusion The mechanical ventilation and the incidence of BPD is significantly reduced in the treatment of neonatal respiratory distress syndrome by LISA, but it has no effect on the incidences of other complications and mortality.
Key words
Full text: 1 Index: WPRIM Type of study: Clinical_trials / Systematic_reviews Language: Zh Journal: Journal of Clinical Pediatrics Year: 2017 Type: Article
Full text: 1 Index: WPRIM Type of study: Clinical_trials / Systematic_reviews Language: Zh Journal: Journal of Clinical Pediatrics Year: 2017 Type: Article