Periprosthetic osteolysis induced by wear particles:research progress of calcineurin/activated T cell nuclear factor signaling pathway / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 1115-1122, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-515277
ABSTRACT
BACKGROUND:
Periprosthetic osteolysis and subsequent aseptic loosening are most common reasons forrevision after total joint replacements. Recently studies found that calcineurin/activated T cell nuclear factor (CN/NFAT) signaling pathway plays important roles in the pathogenic process of wear-induced inflammation and osteolysis.OBJECTIVE:
To summarize CN/NFAT effects on wear particles-induced osteolysis, and to provide new ideas and newtheories for osteolysis-related diseases.METHODS:
We retrieved PubMed for studies published from January 1980 to June 2016. The key words were CN/NFAT, CN/NFAT signaling pathways, wear particles, osteolysis, osteoclasts, osteoblast. Finally, 72 studies were analyzed and explored according to inclusion and exclusion criteria.RESULTS ANDCONCLUSION:
The pathogenesis of osteolysis involves the activation of macrophages by wear particles and the release of various proinflammatory cytokines. Bone is continuously renewed through a dynamic balance between bone resorption and formation and is the fundamental basis for maintaining normal bone mass andarchitecture by osteoclasts and osteoblasts. In this process, CN/NFAT signaling pathway is the signal transduction pathway involved in the differentiation of Ca2+ and nuclear factor kappa B receptor ligand. Osteoclasts play a significant role in both physiological and pathological bone resorption, and receptor activator of nuclear factor-κB ligand is the key cytokine that induces osteoclastogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2017
Type:
Article
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