Burn shock in rats can be treated by abdominal dialysis / 中国病理生理杂志

ABSTRACT

30 Sprague-Dawley rats were used and divided into 3 groupssimple burned (n=12), saline-treated (n=6) and dialysis-treated group (n=12). The trunk below lumbar region and hind extremities of each animal were scalded with 80℃ water for 30 seconds to produce burn shock. In the compensatory stage of shock the blood pressure was not decreased apparently yet microcirculation and electrocardiogram had already been disturbed and becoming severe with the course of disease. When the average arterial blood pressure had lowered to near half of original level after 5 hr of burn, the animals were given abdominal dialysis with balance Krebs solution. In dialysis-treated group, blood pressure and heart rate increased, stagnant capillaries opend up, electrocardiogram partly recovered to near normal and survival time of animals extended significantly as compared with that of simple control or saline-treated group. These indicated that some toxic factors which could be dialysed were prodced after burn and involved in the pathogenesis of burn shock.