Changes of serum level of lipid peroxidation products in rat following burning / 中国病理生理杂志

ABSTRACT

The lumbo-abdominal area and lower extremities of rat were scalded with 80℃ water for 30 seconds (covering about 35—400% TBS) in order to reproduce a model of burn shock. The serum level of malondialdehyde, which is the secondary products of lipid peroxidation, has been measured after burning. The level of products resulting from lipid peroxidation gradually rose up 1-2 hr following scalding. It increased significantly at 3.5 hr and reached to the top level 5 hr after burning. Then it returned down but was still significantly higher than normal at 7 hr post-burn. The administration of peritoneal dialysis with balanced Kreb's solution started just before the appearance of top level (4.5 hr after scalding). The serum level of products fron lipid peroxidation returned to near normal 1.5 hr following peritoneal dialysis. The time course of the change of lipid peroxidation products was similar to that of the development of burn shock, which indicated that the tissue damage from the effect of free radicals might play an important role in the pathogenesis of burn shock.