Study on the fever reaction during hyperthermic ceiling and hyperthermic ceiling plus pyrogen load / 中国病理生理杂志

ABSTRACT

In order to study mechanisms of endotoxin (ET) and endogenous pyrogen (EP) byperthermic ceilings, the febrile responses induced in rabbits by intravenous injection of varying doses of EP were observed, and the doses in which the febrile reactions of rabbits to ET and EP are limited by hyperthermic ceiling were identified. Furthermore, the febrile reactions of typerttermic ceiling plus different pyrogen load were observed. T, e experiment stowed 1. The level of ET hypert ermic ceiling is notably higher in comparison to that of EP hypertiermic ceiling. The findings indicated that the mechanisms of ET fever and ET Lyperthermic ceiling are different from those of EP fever and EP hyperthermic ceiling. 2. After EP hyperthermic ceiling was added the load of ET. the altitude of fever exceeded the EP hyperthermic ceiling; but after ET hypertthermic ceiling was added the load of EP, the altitude couldn't exceed ET hyperthermic ceiling. The results suggested that ET hyperthermic ceiling contained EP hyperttermic ceiling. The latter was an important component of ET hyperttermic ceiling, but there are other factors participating in the mechanisms of ET fever and ET hyperthermic ceiling except EP.