The effects of PGE_1 and arachidonic acid on hypoxic pulmonary pressor response in young pig / 中国病理生理杂志

ABSTRACT

The effects of PGE 1 and AA on hypoxic puImonary pressor response were studied in anesthetized young pig during hypobaric hypoxia simulating 4000 M altitude. After PGE1 injection, Ppa, PVR, Psa and SVR lowered immediately. AA injection enhanced HPPR but diminished Psa and SVR. The results obtained indicated that after AA injection, vasoconstriction PG (VCPG)was produced in pulmonary blood vessels, while vasodilation PG (VDPG)was produced in systemic blood vessels. It seemed that the effect of VCPG was more obvious than that of VDPG on pulmonary vasculature, thus, HPPR was enhanced by the former.