Response to some antitumor agents in epithelial cell line of poorly differentiated nasopharyngeal carcinoma (CNE-2z) / 中国病理生理杂志

ABSTRACT

Using the method to evaluate the cell survival rate in culture, the authors have studied the response of CNE-2z to six kinds of antitumor agents, nitrogen mustard, nitrocaphan, thiophosphoramide, fluorouracil, arabinsyl cytosine, vineristine. The cell survival rate relating to the given dose and lasting time of medicine is observed. Their relationships with different kinds of medicine have shown in different kinds of regression curve and experimental equations that are dependent on their pharmacological actions. The authors also have compared the responses of CNE-2z to each drug in the cell inhibition rate, the ratio of effective inhibiting concentration and therapeutic dosage, and the ratio of LD50 and effective inhibiting concentration. The results indicated that flurouracil may be more effective to nasopharyngeal carcinoma and of wilder safty range in human body.