Studies on cerebrospinal fluid (c.s.f) and plasma cAMP responses during ET and EP hyperthermic ceiling; hyperthermic ceiling plus pyrogen load / 中国病理生理杂志

ABSTRACT

In order to study the mechanisms of ET and EP hyperthermic ceiling the concentration of cAMP in samples of c. s. f. and plasma were measured using the competitive protein binding assay after intraveneous injections of ET and EP in doses of nonhyperthermic ceiling, hyperthermic ceiling and hyperthermic ceiling plus the other pyrogen load. The results showed (1) The concentration of cAMP in c. s. f. was elevated markdly with increase of fever reaction induced by EP, and was limited when EP hyperthermic ceiling was reached. But there was no analogous change of cAMP in plasma. (2) The contents of cAMP both in c. s. f. and in plasma were apparently correlated simultaneously to fever reaction induced by ET, and were limited when ET hyperthermic ceiling was reached. (3) Although the febrele level of ET hyperthermic ceiling was evidently hegher than that of EP and the altitude of fever exceed EP hyyerthermic ceiling when EP hyperthermic ceiling was added the load of ET. Contents of cAMP in c. s. f. had no significant differences among these groups. The results above indicate that the inhibition of central cAMP synthesis is closely related to the formation of EP hyperthermic ceiling and also is one of an important factors that induce. ET hyperthermic ceiling, which, however, is involved in other mediator except cAMP.