Effects of hypoxia and air microembolism of the lung on pulmonary pressor response and lung fluid exchange in conscious goats / 中国病理生理杂志

ABSTRACT

The effects of hypoxia and air microembolism on pulmonary pressor response and lung fluid exchange were studied in eight conscious goats with chronic lung lymph fistula. The results indicate (1). The site of pulmonary vasoconstriction induced by hypoxia may be precapillary. Hypoxia (4000m-simulated high altitude) induces no pulmonary microvascular injury. (2). Air microembolism results in elevation in Ppa and increase in pulmonary microvascular permeability, (3). Air microembolism in hypoxic animal induces further increase in Ppa. But the amplitude of pressor response induced by hypoxia in combination with air microembolism is not the summation of those induced by either of them acting separately. (4). Hypobaric hypoxia(4000m-simulated high altitude) does not aggravate air microembolism-induced lung injury.