Role of cardiac-cardiac sympathetic reflex in the hemorheologic changes caused by acute coronary occlusion / 中国病理生理杂志

ABSTRACT

The changes in flow properties of blood draining-from ischemic area and from systemic circulation causad by acute coronary occlusion were studied in 21 anesthe- tized open-chest dogs and the role of cardiac-cardiac sympathetic reflex in these changes was analysed. The main results obtained were as in the following 1. The obvious hemorhoblogic changes were detected at the early phase of myocardial ischemia and the more significant change in high shear viscosity of whole blood was observed in coronary venous blood draining from ischemic area; 2. Topical application of lidocaine to the ischemic area of the heart virtually abolished the hemorheologie changes in systemic venous blood caused by coronary occlnsion, but had no significant effect on the change in high shear viscosity of blood draining from the ischemic area; 3. Bilateral section of stellate ganglia had no effect on the changes in hemorheologe following coronary occlusion. The results mentioned above suggested that increased activity of cardiac sympathetic nerves which originated from ischemic area had an important role in causing hemorheologic changes following coronary occlusion.