The effect of normobaric hypoxia on the density of ? and ?_1 adrenoceptors in the rat lung / 中国病理生理杂志

ABSTRACT

The rats were kept in normobaric hypoxic chamber(O_2=10%) for 24 hours or 1,2,4 weeks(6 hrs./day, 6day/wk.). The adrenoeeptors of lungs were measured by binding study. The result showed that The beta adrenoceptors decreased by 24 hours of hypoxia and unexpectedly increased at 1 week of hypoxia. The exposure to hypoxia for 2 and 4 weeks led to a decrease in beta adrenoceptors again. By contrast, the alpha adrenoceptors increased markedly at 24 hours and 4 weeks of hypoxiao A higher, but not significant density of alpha_1 adrenoceptors was also found at 1 and 2 weeks of hypoxia. The affinity of beta and alpha_1 adrenoceptors did not change after hypoxia. The data indicated that the changes in adrenoceptors induced by hypoxia may play a role in the development of hypoxic pulmonary hypertension.