Alteration of Enzyme Activities in Mitochondria and cAMP Content in Cortex of Brain During Acute Ischemia in Monkeys / 昆明医科大学学报

ABSTRACT

CPK activity in mitochondria of brain cells was increased following 15 and 30 minutes of ischemia,by four-vessel occlusion in ten monkeys.It sugested that there was a compensatory elevated degradation of energy-rich phosphate during ischemia.while the energy-rich phos- phate degradation was exhausted as ischemia duration extended.At 60 minutes of ischemia the activity of CPK was fallen.Isocittate dehydrogenase activity in mitochondria of brain cells was declined,the more ischemic duration extended,the more the activity decreased. LDH activity in the brain cells was raise after onset ischemia and then diminished.cAMP content in cerbral cortex was decreased after 15 minutes of ischemia,whilst it elevated after 30 minutes of ischemia.The possible mechanism of changes mentioned above was discussed.