Experimental Studies of Inducing Lung Cancer on Hamsters by Seven Chemical Elements in Yunnan Tin Mine Dust / 昆明医科大学学报

ABSTRACT

There is a high incidence of Lung cancer among the miners of Yunnan Tin Mine.In or- der to study the carcinogenicity of chemical elements with none radioactive in the mine pow- der,a mixture of seven non-radioactive,inorganic chemical elements(CM_2As,Pb,Fe, Cr,Ni,Cd and Be)relating to mutagenicity and tumorgenesis were chosen for Ames test and carinoma inducing experiments in hamsters.The results are as follows1 Ames test of CM_2is positive.2 The lung cancer inducing experiment of CM_2on hamsters is successful.Lung cancer and precancerous lesions develop in 6 of 27 effective animals, the incidence is 22.2%.No tu- mor was found in the control group.The results show that CM_2is related to the lung cancer formation of hamsters,tihs is reported for the first time.