Comparison of the effects of anisodamine and dopamine on renal microcirculation / 中国病理生理杂志

ABSTRACT

Effects of anisodamine on renal microcirculation were compared with that of dopamine. A vasodilation in the preglomerular vessels at concentrations from 10~(-6)--10~(-4)M of both anisodamine and dopamine were measured and the dilatory response of anisodamine in the proximal interlobular artery was higher than that of dopamine. Bath at concentrations of 10~(-3)M, anisodamine caused the vasodilation of all the preglomerular vessels, but dopamine elicited the vasoconstriction of preglomerular vessels except for the afferent arteriole near to the glomerulus. A vasoconstriction of the arterioles which drain the glomeruli was found with topical application of anisodamine from 10~(-6) to 10~(-3) M but dopamine only at 10~(-3) M. After pretreatment with haloperidol the effects on pre-and postglomerular vessels of anisodamine at all concentrations and dopamine at low concentrations were abolished, but at higher concentrations the effect of dopamine was not blocked. The results indicated that a better therapeutic efficacy of anisodamine in clinical use might be dependent upon its vasodilatory response of preglomerular vessels without the biphasic effect of dopamine and also depends on its vasoconstriction of postglomerular vesseles.