Ouantum Chemical Study on Catalytic Mechanism of Serine Proteases / 昆明医科大学学报
Journal of Kunming Medical University
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-515964
ABSTRACT
Using the semiempirical MNDO method,several systems simulating the active site of serine proteases have been studied.The stabilization energy was found depending strongly on the nucleophilicity of the attacking group.the decrease of the activation energy has been esti- mated at 9 kca/mole.It was shown that the substrate distortion did not vary with the form- ing of hydrogen bonds.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Kunming Medical University
Year:
1986
Type:
Article
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