Effect of ahalysantinfarctasum on acute alveolar hypoxic pulmonary hypertension / 中国病理生理杂志

ABSTRACT

The effect of ahalysantinfarctasum (AFT) on acute hypoxic pulmonary hypertension of dogs was examined. The'decrease in pulmonary vascular resistance and a dose dependent attenuation of acute hypoxic pulmonary vasoconstriction by AFT were found. AFT did not alter systemic vascular resistance. PaO_2 and PaCO_2 6-keto-PGF_(1?) increased significantly, however after the intravenous infusion of AFT, TXB_2 did not change. It is suggested that AFT may attenuate hypoxic pulmonary vasoconstriction by tnducing the synthesis or release of PG I to nreyent nulmonary hypertension