The effect of captopril on rabbits hemorrhagic shock / 中国病理生理杂志

ABSTRACT

This paper reported the effect of captopril (SQ14225) on rabbits hemorrhagic shock. After late hemorrhagic shock model (MABP 40mmHg, maintained for 90min) was replicated, 26 rabbits were divided randomly into a captopril-treated group (n=13) and a control group (n=13). In the treated group, captopril(1mg/kg) was infused with normal saline (15ml/kg), low molecular dextran (15ml/kg)and shed blood, an hour later, the MABP, CVP and renal blood flow rose markedly, the platelet aggregation was significantly lowered and mesenteric microcireulation was improved remarkably. Three hours later, the various indexes mentioned above returned almost to normal (before the shock). The survival rate in 5 hours was 91.7%. The difference between the control and the treated group was quite significant (P